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The glamorous Mae West (My Little Chickadee) stars as a "kept" woman who flees to Alaska and the Gold Rush of the 1890s in Klondike Annie. After the beautiful Rose Carlton (West) escapes from the clutches of the wealthy and possessive Chan Lo (Harold Huber, The Thin Man), she finds herself on a ship bound for greater pastures. The ship's captain, Bull Brackett (Victor McLaglen, The Informer), instantly falls for Rose but she is distracted by her new cabin mate, Sister Annie Alden (Helen Jerome Eddy, Madame Butterfly). Exchanging philosophies, the unlikely pair develop a meaningful friendship before Sister Annie becomes sick and passes on. In desperation, as her past starts to catch up with her, Rose changes her identity with her deceased friend and is inspired to a new calling. West is at her best as she brings the immoral townspeople to their knees with her unconventional style of evangelism in this spirited tale of divine transformation.