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With the collapse of the Russian government, a highly contagious and deadly virus is loosed upon the world. Boston is quarantined and turned into a militarized zone. Police officer Delon (Natasha Henstridge) is about to leave the city with her son when a series of gruesome killings reveals that someone has brought the virus to Boston. When Delon and her partner, Lemieux (Christopher Lambert), are sent to investigate, they quickly find themselves in danger.