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Unemployed degenerate Kaiji Ito spent his time drinking, gambling, and racking up bills, and was sure that his life had hit rock bottom. Then that bottom fell out when Endo the Loan Shark arrived to inform him of a friend's default on a loan that Kaiji foolishly co-signed, making Kaiji responsible for a soul crushing 3,000,000 yen! But there is one possible way out; if Kaiji goes to a secret gambling ship and plays successfully for one night, his debt could be absolved. It's a trick, of course, but what choice does Kaiji have?
Trapped into playing a series of increasingly ruthless contests that are hopelessly rigged against the players, Kaiji finds himself a pawn in a competition where the game pieces aren't expected to survive… and the real players are all actively betting against Kaiji!