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The Devil's Advocates—an outlaw gang of Harley-riding hellions led by Adam (Stephen Oliver, The Naked Zoo, Motorpsycho!) and his old lady Helen (Donna Anders, Count Yorga, Vampire)—troll the dusty highways of the American Southwest in search of the next great kick, whether it be sex, drugs, or violence. After dispatching a pair of rednecks unfriendly to their lifestyle, the Advocates run roughshod over a gas station before taking to the road again, where they encounter a cloistered sect of Satanic Monks led by high priest One (Severn Darden, Battle for the Planet of the Apes). A mass-drugging, a ritual sacrifice, a topless snake-dance, and a scene-clearing fistfight ensue but it's too late; the spell has been cast, and the two shall become... Werewolves on Wheels!