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Dr. Frederick Cleveland and his daughter Janet are joined by scientific researcher Wayne Brooks in the pursuit of ancient artifacts from Vargas, a giant 500-year-old Spanish conquistador. When a lightning storm interrupts their search, the team finds much more than artifacts when the long-lost Vargas returns to life, with a murderous rage and an axe to grind! With a shock a minute, Giant from the Unknown (1958) features make-up design from horror mainstay Jack Pierce, known for his work on Frankenstein (1931) and The Mummy (1932).