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Abby (Kat Dennings) is looking forward to a laid-back Thanksgiving with her best friend, Molly (Malin Akerman). But the friends' plans for a quiet turkey dinner go up in smoke when they're joined by Molly's new boyfriend and her flamboyant mother (Jane Seymour). Throw in some party crashers including Molly's old flame, a wannabe shaman, and a trio of Fairy Gay Mothers (Wanda Sykes, Margaret Cho, and Fortune Feimster), and it's a recipe for a comically chaotic holiday no one will ever forget — even if they wanted to!