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Four ninjas with kekkei genkai who have been guarding the Hidden Villages of Cloud, Stone, Mist and Sand disappear from their respective villages. The Land of Fire comes under suspicion as it is the only country to have suffered no loss. Mounting suspicion among the four countries almost brings about a 4th Great Ninja War. In the Hidden Village of Leaf, Tsunade orders her men to keep strict guard against War and to try to find out what really happened. At the same time, it turns out that Kakashi has left the village. The bad news deeply disturbs Naruto and his friends.