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In 1856, slave Eliza (Margarita Fischer) plans to marry George (Arthur Edmund Carew) with the consent of the Shelbys, her masters, but George's owner prevents the wedding. A few years later, Eliza flees with her son, Harry (Lassie Lou Ahern), after learning the Shelbys plan to hand them over to a crooked creditor to prevent foreclosure. George also escapes and goes on the run while Eliza and Harry are captured and brought back home. Mother and son are separated as George tries to find them both.