Life (1999)

Rayford Gibson, an opportunistic con man, and Claude Banks, an ambitious bank teller, are complete opposites who cross paths in 1930s Harlem. In order to pay off their debts to a local crime lord, the mismatched pair travel into the Deep South on a moonshine delivery only to be framed for murder by a racist Southern cop. Sentenced to life in a Mississippi state prison, the bickering duo spend the next 60 years trading barbs and planning their escape, at the same time forming an unlikely but touching friendship.