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Darkman, needing money to continue his experiments on synthetic skin, steals a crate of cash from drug lord Peter Rooker, attracting the gangster's attention. Rooker is determined to find the source of Darkman's super strength, and uses his beautiful but evil doctor to lure Darkman into a trap. Thinking that the doctor will restore feeling to his tortured body, he discovers too late that they have taken a sample of his adrenaline, which they will market as a super steroid. As Darkman plans his revenge on Rooker's gang, he slowly begins to care about Rooker's neglected wife and daughter. He must now find a way to help them, and destroy Rooker before he uses the adrenaline to plunge the city into chaos.