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Orphaned at an early age, Peter Parker lives in Queens, New York with his beloved Aunt May and Uncle Ben. Peter leads the life of a normal student, working as a photographer at the school paper, pining after the beautiful Mary Jane Watson and hanging out with buddy Harry Osborn. On a school trip, during which Peter and his classmates are given a science demonstration on arachnids, Peter is bitten by a genetically-altered spider. Soon after, he discovers that he has unusual powers: he is endowed with the strength and agility of a spider along with a keen, ESP-like "spider-sense." He vows to dedicate his life to fighting crime, taking to heart the words of his beloved Uncle Ben: "With great power comes great responsibility."
