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Caleb and Camille Fang (Christopher Walken and Maryann Plunkett) are a couple famous for their public, avant-garde comedy skits that featured their children, previously known as Child A and Child B. Now adults with successful showbiz careers of their own, Annie (Nicole Kidman) and Buster Fang (Jason Bateman) are estranged from their parents and lament their exploitation as children. However, when Caleb and Camille go missing at a bloody crime scene, Annie and Buster reunite at their childhood home to determine if their parents are truly in trouble or if their disappearance is their final career ruse.