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A group of medical students at Forthaven General Hospital study hard and party harder, until a cruel prank accidentally puts the hospital's creepy caretaker into a deep coma. But when Catherine (Arielle Kebbel) tries to revive the degenerate loner with an experimental drug, she instead sends his brainwaves beserk.
It’s not long before Catherine’s friends are picked off one-by-one in a spree of sick kicks as the ultimate out-of-body experience ushers in a bloodbath of brutal revenge.