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Times are hard for Toxie. What's a hideously deformed creature of superhuman size and strength to do after he's eliminated crime from his hometown? Desperate to raise money for the experimental surgery that could restore his blind fiancée's eyesight, Toxie accepts a lucrative job with the evil multinational conglomerate Apocalypse Inc.
Now, Toxie's transforming into an even more monstrous creature: a yuppie. And all of Tromaville is paying the price of Toxie's Faustian bargain. The Toxic Avenger must defeat his own inner demons before taking on the Devil himself in a battle royale, while the fate of Tromaville hangs in the balance.