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Clear the runway for Derek Zoolander (Stiller), VH1's three-time Male Model of the Year. His face falls, though, when hippie-chic Hansel (Owen Wilson) scooters in to steal the latest award. Meanwhile, the evil fashion mogul Mugatu (Will Ferrell) seizes the opportunity to brainwash Derek, turning him into a killing machine that, when triggered, will assassinate the Prime Minister of Malaysia. With the help of the beautiful journalist Matilda (Christine Taylor), Derek races to keep the world safe for male models everywhere.