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Overworked Bob Munro (Robin Williams), his wife Jamie (Cheryl Hines), their 15-year-old daughter Cassie (Joanna “JoJo” Levesque) and 12-year-old son Carl (Josh Hutcherson) are in desperate need of some quality time together. After promising to take them on a family vacation in Hawaii, Bob abruptly changes plans: Instead of a week in a tropical paradise, they're going on a road trip to Colorado in a recreational vehicle. In Bob's togetherness plan (which is a ruse to keep him from losing his job), everything that can go wrong, does. And every attempt Bob makes to get the family into the spirit of the vacation threatens to tear them further apart. But adversity has a way of uniting even the most dysfunctional family, and each setback the Munros experience inadvertently helps them become a true family again.