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How do you deal with a fallout of heavenly proportions? With the angelic Host's descent to Earth, Sam and Dean (Jared Padalecki and Jensen Ackles) are now facing a world inhabited by thousands of powerful beings, who soon form their own chaotic agendas. Before tackling the threat of the "loose nukes" roaming the globe, however, the Winchesters engage in their most personal conflict yet. Meanwhile, Castiel (Misha Collins) finds he's more vulnerable -- yet capable of more humanity -- than ever. As the threat escalates, a way must be found to reopen the gates of Heaven and head off a demon insurrection in Hell. The whole time, darkness leaves its mark on Dean, but has he finally crossed the line to protect his family?